Langton was born in Arizona to Jackson Langton, a geologist, and a surgical nurse mother. Her maternal grandfather, Steven Cummings, was a WWII pilot, and her aunt, Sally Spalding, is a script supervisor. She was raised in Texas.

Over the years, she has dated a number of well-known celebrities, including actors George Clooney and David Chokachi, golfer Tiger Woods and Internet executive Carl Hagmier.

Langton came to fame on the television series Melrose Place, playing Samantha Reilly Campbell. After Melrose Place, she starred in The Net (TV series), a television drama based on the 1995 film of the same name. Langton starred as Angela Bennett, the character played by Sandra Bullock in the film. It was produced in Vancouver, Canada, it originally aired on the USA Network.

She also appeared alongside Keanu Reeves and Gene Hackman in the 2000 film The Replacements, and had a brief role in the 1996 indie film Swingers. In addition to these films, she has starred in a number of smaller films like Partners with Jay Harrington and Julie Bowen, Playing Mona Lisa with Alicia Witt, and Kiss the Bride with Alyssa Milano. Her most recent film role was in the film Primeval, which was released in January of 2007, as well as an appearance in the video for the song (You Want To) Make A Memory by Bon Jovi. She's also cast in a lead role in the film The Kingdom, which is set to be released in 2007.