Lori Loughlin began her career at age twelve as a print model. During her early teen years she appeared in television commercials, and was frequently seen in national print ads like the Sears catalog and Bradlees weekly flyers.

At the age of 15, Lori was cast on ABC's soap opera, The Edge of Night playing the part of Jody Travis, an aspiring dancer. After three-and-a-half years, prompted by the urging of her fellow actor, the late Joel Crothers, Lori decided to try her luck in feature films and television. Lori's most well known role to date has been that of Rebecca Donaldson on Full House.

In 1997, she and Bruce Campbell played husband-and-wife bank robbers in In the Line of Duty: Blaze of Gory.

In 2000, Lori co-starred opposite Treat Williams in the Fred Olen Ray-helmed thriller Critical Mass.

From 2004 to 2005, Loughlin co-created, produced and starred in The WB drama series Summerland. She played Ava, the aunt of three children which she has to raise due to an unfortunate car accident, in which their parents died. The series, now cancelled, finished on July 11, 2005.

In 2006, Loughlin began filming for the film "Moondance Alexander," a film in which she will co-star with Kay Panabaker.

She is 5' 6 (1.68 m), measurements: 33-25-35 (as an Elite model 1982).

She married Michael Burns in 1989, but they divorced in 1996. She is now married to Mossimo Gianulli, whom she married on November 25, 1997; they have 2 children. 1st Daughter Isabella Rose, born (7 lb. 3 oz.) on September 16, 1998, 2nd daughter, Olivia Jade, born in L.A. on September 28, 1999. Her husband, Mossimo Giannulli, is the creator of the popular "Mossimo" clothing line.