Bedingfield was born in Sussex but raised in Lewisham to New Zealand parents.

As a teenager, Natasha, Daniel and younger sister Nikola formed the Christian worship band, The DNA Algorithm. In it they experimented with a variety of music, from R&B to garage rock, and would occasionally perform small gigs.

After school Bedingfield decided to attend university instead of art college, as the college noted that she seemed to be more interested in the emotional content of her artwork, leading her to study psychology. Bedingfield commented on her choice stating: "But even then, I was interested in psychology because I knew that'd make me a better songwriter. It'd give me a deeper insight into people. I was sick of empty music - people whip up a melody then any kind of words to fit. I'm not interested in lines that go 'blah blah blah.' I want something that provokes me as well as the listener."

As a member of Hillsong London church, Bedingfield was one of the congregation’s worship leaders. She also co-wrote several songs recorded on the church’s album Shout God's Fame as well as a song "All I Do" featured on an album called Blessed by Hillsong Music Australia. A different version of the song (along with another co-written by Bedingfield "You Are My Rock") can be found on Hillsong Kiev’s album Ðåâîëþöèÿ (Revolution), and Bedingfield is a co-performer of both songs.

On May 3, 2004, the song "Single", was released as Bedingfield’s debut single in the UK. The song peaked at #3 and spent 10 weeks inside the UK Top 75. Three months later, Bedingfield released her second single, "These Words". The song performed even better than her debut, going straight to #1.

After the success of "These Words", Bedingfield released her debut album, Unwritten, on September 6, 2004. It debuted at #1. The album has sold over 900,000 copies in the UK to date, and is certified 3x Platinum.

The song "Unwritten" was released as Bedingfield’s third single on November 29, 2004. It peaked at a #6 (although it would prove much more successful in the US a year later). She then took an unusually long 5-month break until finally releasing the fourth single, "I Bruise Easily". The song underperformed, peaking at #12 and getting only seven weeks inside the Top 75 (It was arguably a minor hit seeing as the album had been out for quite some time.)

In May 2005, "These Words" was released to US radio stations as Bedingfield’s debut US single. It was chosen over her UK debut, "Single", due to its worldwide success on the charts. In June, the video began to receive excessive play on VH1 and MTV. The song peaked at #17 on the Billboard Hot 100 . The US position is one of the lowest worldwide for the song "These Words".

On July 26, 2005, the Unwritten album was released in the US. Initially, sales were below average. The album debuted and peaked at #26, selling 30,000 copies in its first week. It then quickly dropped. It was clear that a new single was needed to boost sales. "Unwritten" was released as the second US single in November of 2005. The song took a while to increase in popularity. 21 weeks after its release, the song reached its peak at #5 (much better than her first single due to its heavy radio rotation, downloads, and like "These Words", extensive music video play). It became one of the most successful songs of 2006 selling over 1,000,000 digital downloads (one of a handful singles to sell over a million downloads). It spent over 30 weeks on the chart.

Like Bedingfield’s US label had hoped, the Unwritten album made it's way back into the Top 200, and has remained in the lower part of the top 100. To date the album has sold over 600,000 copies in the US and is certified Gold. Her song, 'The One That Got Away', was released to radio and became a hit on the US Dance Charts, peaking at #1 on the US Dance Club Play chart, and #4 on the US Hot Dance Airplay chart.

The third single released in the US was "Single". It debuted at #72 on the Hot 100 (her highest debut yet). Despite the high debut, the video and song recieved much less play than her previous two. "Single" became her lowest charting single in the US, peaking only at #57. The main reason for the failure of Single was because of the massive success of Unwritten and radio's refusal to stop playing Unwritten which reduced the chances for Single to succeed in the US.

Due to the less than spectacular performance of "Single", it is unknown if a 4th single will be released. ("I Bruise Easily" would be the likely candidate.)

"Unwritten" is the theme song for MTV's reality show The Hills.

At the request of Sylvester Stallone himself, she has recorded the title song to Rocky Balboa, "Still Here," written by Diane Warren. She was also asked by the star to appear on screen.